Upstream Bio Inc (UPB) is trading up at $2.99 (+6.79%), as of the latest quote. It is a Russell 2000 constituent in the Health Care sector.
| FY2023Dec 2023 | FY2024Dec 2024 | FY2025Dec 2025 | |
|---|---|---|---|
| Income statement | |||
| Revenue | $2.38M | $2.37M | $2.85M |
| Growth (year over year) | — | −0.4% | +20.4% |
| Operating income | −$40.1M | −$77.8M | −$160.4M |
| Operating margin | −1685.5% | −3281.2% | −5618.8% |
| Net income | −$20.5M | −$62.8M | −$143.4M |
| Net margin | −862.9% | −2650.0% | −5026.0% |
| EPS (diluted) | −$12.95 | −$5.58 | −$2.66 |
| Balance sheet | |||
| Cash and equivalents | $25.8M | $325.9M | $101.6M |
| Total assets | $117.2M | $481.7M | $353.8M |
| Total liabilities | $9.39M | $11.9M | $14.0M |
| Shareholders' equity | −$123.1M | $469.9M | $339.8M |
| Cash flow | |||
| Operating cash flow | −$37.9M | −$59.2M | −$133.3M |
| Capital expenditure | $144.0K | $511.0K | $165.0K |
| Free cash flow | −$38.1M | −$59.7M | −$133.4M |
| Q3 FY24Sep 2024 | Q4 FY24†Dec 2024 | Q1 FY25Mar 2025 | Q2 FY25Jun 2025 | Q3 FY25Sep 2025 | Q4 FY25†Dec 2025 | Q1 FY26Mar 2026 | Q2 FY26Jun 2026 | |
|---|---|---|---|---|---|---|---|---|
| Income statement | ||||||||
| Revenue | $607.0K | $613.0K | $566.0K | $937.0K | $683.0K | $668.0K | $1.03M | $773.0K |
| Growth (year over year) | −2.3% | +36.2% | −11.6% | +83.7% | +12.5% | +9.0% | +82.7% | −17.5% |
| Operating income | −$18.9M | −$26.3M | −$32.0M | −$44.3M | −$37.8M | −$46.2M | −$43.6M | −$42.4M |
| Operating margin | −3112.5% | −4293.3% | −5656.0% | −4732.9% | −5539.4% | −6911.2% | −4218.1% | −5481.0% |
| Net income | −$16.0M | −$21.2M | −$27.3M | −$40.0M | −$33.7M | −$42.5M | −$40.6M | −$39.7M |
| Net margin | −2634.6% | −3465.3% | −4818.0% | −4265.3% | −4941.1% | −6356.1% | −3925.6% | −5136.1% |
| EPS (diluted) | −$6.96 | $12.56 | −$0.51 | −$0.74 | −$0.63 | −$0.78 | −$0.75 | −$0.73 |
| Balance sheet | ||||||||
| Cash and equivalents | $32.9M | $325.9M | $71.3M | $45.5M | $72.2M | $101.6M | $96.7M | $79.4M |
| Total assets | $232.7M | $481.7M | $456.2M | $420.5M | $391.2M | $353.8M | $318.1M | $281.2M |
| Total liabilities | $12.1M | $11.9M | $10.6M | $11.8M | $12.6M | $14.0M | $14.1M | $10.2M |
| Shareholders' equity | −$160.3M | $469.9M | $445.6M | $408.7M | $378.6M | $339.8M | $304.0M | $271.0M |
| Cash flow | ||||||||
| Operating cash flow | −$14.0M | −$19.6M | −$41.2M | −$39.2M | −$22.2M | −$30.6M | −$47.9M | −$35.6M |
| Capital expenditure | — | $185.0K | — | — | $64.0K | $54.0K | — | — |
| Free cash flow | — | −$19.8M | — | — | −$22.3M | −$30.7M | — | — |
From Upstream Bio Inc's 10-K and 10-Q filings with the SEC; its fiscal year ends in December. Each period shows the latest figure the company has reported for it, including restatements. Net margin is our own calculation from those reported figures (net income ÷ revenue); it is left blank where revenue is zero or missing. † Quarter derived from the company's year-to-date or full-year totals. Filings on SEC EDGAR →
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